Acetyl chloride → HCID 57974288, compound

Participants

Reaction Steps

The procedure described in Example 5 was repeated using N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-{2-[(1-methylpiperidin-4-yl)amino]ethoxy}quinazolin-4-amine and acetyl chloride to give the title compound in 41% yield; NMR spectrum (DMSO-d6) 1.62-1.90 (m, 4H), 2.09 (s, 3H), 2.15-2.43 (m, 4H), 2.79-3.13 (m, 3H), 3.76-3.83 (m, 2H), 3.86-3.92 (m, 1H), 4.30-4.47 (m, 2H), 5.31 (s, 2H), 7.21 (d, 1H), 7.26 (d, 1H), 7.32-7.40 (m, 2H), 7.57-7.61 (m, 2H), 7.69-7.75 (m, 1H), 7.86-7.92 (m, 1H), 7.98-8.00 (m, 1H), 8.46 (s, 1H), 8.61 (d, 1H), 9.95 (s, 1H); Mass spectrum MH+ 561.

Provenance & Evidence