Acetyl chloride → HCID 11192056, compound

Participants

Reaction Steps

The procedure described in Example 5 was repeated using N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(tetrahydro-2H-pyran-4-ylamino)ethoxy]quinazolin-4-amine and acetyl chloride to give the title compound in 68% yield; NMR spectrum (DMSO-d6) 1.49-1.71 (m, 2H), 1.75-1.98 (m, 2H), 2.11 (s, 3H), 3.36-3.45 (m, 2H), 3.78-3.96 (m, 5H), 4.26-4.46 (m, 2H), 5.31 (s, 2H), 7.22 (d, 1H), 7.26 (d, 1H), 7.33 (d, 1H), 7.35-7.40 (m, 1H), 7.56-7.63 (m, 2H), 7.69-7.75 (m, 1H), 7.86-7.91 (m, 1H), 7.99-8.03 (m, 1H), 8.46 (s, 1H), 8.61 (d, 1H), 9.98 (s, 1H); Mass spectrum MH+ 548.

Provenance & Evidence