反应详情

The procedure described in Example 1 was repeated using 2-hydroxy-2-methylpropanoic acid and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(methylamino)ethoxy]quinazolin-4-amine (obtained as described in Example 1, preparation of starting materials) to give the title compound in 39% yield; NMR spectrum (DMSO-d6) 1.20 (s, 6H), 3.34 (s, 3H), 3.89 (s, 2H), 4.43 (s, 2H), 5.27 (s, 1H), 5.31 (s, 2H), 7.18 (d, 1H), 7.24 (d, 1H), 7.32-7.40 (m, 2H), 7.53-7.57 (m, 1H), 7.58 (d, 1H), 7.70-7.76 (m, 1H), 7.86-7.91 (m, 2H), 8.43 (s, 1H), 8.59-8.61 (m, 1H), 9.75 (s, 1H); Mass spectrum MH+ 522.