1-Hydroxy-1-cyclopropanecarboxylic acid → HCID 57974323, compound

Participants

Reaction Steps

The procedure described in Example 1 was repeated using 1-hydroxycyclopropanecarboxylic acid and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(methylamino)ethoxy]quinazolin-4-amine (obtained as described in Example 1, preparation of starting materials) to give the title compound in 54% yield; NMR spectrum (DMSO-d6) 0.68-0.80 (m, 4H), 3.30 (s, 3H), 3.84-3.96 (m, 2H), 4.37-4.49 (m, 2H), 5.31 (s, 2H), 6.16-6.23 (m, 1H), 7.14-7.21 (m, 1H), 7.24 (d, 1H), 7.32-7.40 (m, 2H), 7.51-7.56 (m, 1H), 7.59 (d, 1H), 7.71-7.76 (m, 1H), 7.86-7.91 (m, 2H), 8.40-8.47 (m, 1H), 8.61 (d, 1H), 9.68-9.75 (m, 1H); Mass spectrum MH+ 520.

Provenance & Evidence