3-Hydroxypropionic acid → HCID 11191405, compound

Participants

Reaction Steps

The procedure described in Example 1 was repeated using 3-hydroxypropanoic acid and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(methylamino)ethoxy]quinazolin-4-amine (obtained as described in Example 1, preparation of starting materials) to give the title compound in 24% yield; NMR spectrum (DMSO-d6) 2.13-2.26 (m, 2H), 2.65-2.79 (m, 2H), 3.30 (s, 3H), 3.87-3.97 (m, 2H), 4.13-4.25 (m, 1H), 4.34-4.61 (m, 2H), 5.31 (s, 2H), 7.15 (d, 1H), 7.25 (d, 1H), 7.32-7.39 (m, 2H), 7.53-7.57 (m, 1H), 7.60 (d, 1H), 7.70-7.76 (m, 1H), 7.86-7.92 (m, 2H), 8.42 (s, 1H), 8.61 (d, 1H), 9.70 (s, 1H); Mass spectrum MH+ 508.

Provenance & Evidence