Glycolic Acid → N-{2-[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]ethyl}-2-hydroxyacetamide

Participants

Reaction Steps

The procedure described in Example 1 was repeated using glycolic acid and 5-(2-aminoethoxy)-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]quinazolin-4-amine (obtained as described in Example 2.6, preparation of starting materials) to give the title compound in 60% yield; NMR spectrum (DMSO-d6) 3.71 (q, 2H), 3.78 (d, 2H), 4.36 (t, 2H), 5.28 (s, 2H), 5.49 (t, 1H), 7.13 (d, 1H), 7.21 (d, 1H), 7.32 (d, 1H), 7.35 (m, 1H), 7.56 (m, 2H), 7.71 (t, 1H), 7.87 (dt, 1H), 7.98 (d, 1H), 8.18 (t, 1H), 8.45 (s, 1H), 8.58 (d, 1H), 9.82 (s, 1H); Mass Spectrum MH+ 480.

Provenance & Evidence