N,N-Dimethylglycine → N1-{2-[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]ethyl}-N2,N2-dimethylglycinamide

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Reaction Steps

The procedure described in Example 1 was repeated using N,N-dimethylglycine and 5-(2-aminoethoxy)-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]quinazolin-4-amine (obtained as described in Example 2.6, preparation of starting materials) to give the title compound in 31% yield; NMR spectrum (DMSO-d6) 2.08 (s, 6H), 2.79 (s, 2H), 3.68 (q, 2H), 4.36 (t, 2H), 5.29 (s, 2H), 7.13 (d, 1H), 7.21 (d, 1H), 7.34 (m, 2H), 7.55 (m, 2H), 7.70 (t, 1H), 7.86 (dt, 1H), 7.98 (d, 1H), 8.11 (t, 1H), 8.45 (s, 1H), 8.58 (d, 1H), 9.80 (s, 1H); Mass Spectrum MH+ 507.

Provenance & Evidence