N,N-Dimethylglycine → HCID 57974305, compound

Participants

Reaction Steps

The procedure described in Example 1 was repeated using N,N-dimethylglycine and 5-{[(2S)-2-aminopropyl]oxy}-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]quinazolin-4-amine to give the title compound in 42% yield; NMR spectrum (DMSO-d6) 1.21 (d, 3H), 2.05 (s, 6H), 2.60-2.80 (m, 2H), 4.20-4.40 (m, 2H), 4.40-4.60 (m, 1H), 5.30 (s, 2H), 7.15 (m, 1H), 7.22 (m, 1H), 7.35 (m, 2H), 7.54 (m, 2H), 7.70 (t, 1H), 7.90 (t, 1H), 7.98 (m, 2H), 8.48 (s, 1H), 8.59 (d, 1H), 9.76 (s, 1H); Mass spectrum MH+ 521.4.

Provenance & Evidence