HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Alaninol → HCID 69059443, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Alaninol | HCID 80307 | — |
| Reactant | N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-fluoroquinazolin-4-amine | HCID 57444972 | — |
| Product | HCID 69059443 | HCID 69059443 | 51% |
Reaction Steps
The procedure described in Example 2.4 (preparation of starting materials) was repeated using (2S)-2-aminopropan-1-ol and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-fluoroquinazolin-4-amine (obtained as described in Example 1, preparation of starting materials) to give 5-{[(2S)-2-aminopropyl]oxy}-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]quinazolin-4-amine in 51% yield; Mass spectrum MH+ 436.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07625908B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-3abe7d018afd45a4862024ebcc2de982 |
| Source note | uspto-grants-2009_12 |