Picolyl chloride hydrochloride → HCID 57974315, compound

Participants

Reaction Steps

The procedure described in Example 3 was repeated using N1-[(2R)-2-({4-[(3-chloro-4-hydroxyphenyl)amino]quinazolin-5-yl}oxy)propyl]-N2,N2-dimethylglycinamide and picolyl chloride hydrochloride to give the title compound in 59% yield; NMR spectrum (CDCl3) 1.47 (d, 3H), 2.11 (s, 6H), 2.88 (s, 2H), 3.50-3.63 (m, 1H), 3.64-3.78 (m, 1H), 4.76-4.90 (m, 1H), 5.23 (s, 2H), 6.92-7.00 (m, 2H), 7.13-7.19 (m, 1H), 7.36-7.49 (m, 2H), 7.52-7.72 (m, 4H), 7.90 (d, 1H), 8.55 (m, 2H), 9.82 (s, 1H); Mass spectrum MH+ 521.0.

Provenance & Evidence