2-Hydroxy-gamma-butyrolactone, (2R)- → HCID 57974313, compound

Participants

Reaction Steps

The procedure described in Example 63 was repeated using 5-{[(2R)-2-aminopropyl]oxy}-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]quinazolin-4-amine (obtained as described in Example 2.4, preparation of starting materials) and (R)-(+)-α-hydroxy-γ-butyrolactone to give the title compound in 77% yield; NMR spectrum (DMSO-d6) 1.22 (d, 3H), 1.46-1.60 (m, 1H), 1.72-1.86 (m, 1H), 3.38-3.51 (m, 2H), 3.83-3.93 (m, 1H), 4.20-4.40 (m, 3H), 4.42-4.55 (m, 1H), 5.29 (s, 2H), 5.39 (d, 1H), 7.14 (d, 1H), 7.21 (d, 1H), 7.30-7.40 (m, 2H), 7.47-7.55 (m, 1H), 7.58 (d, 1H), 7.72 (t, 1H), 7.87 (t, 1H), 7.97 (d, 1H), 8.01 (s, 1H), 8.46 (s, 1H), 8.59 (d, 1H), 9.74 (s, 1H); Mass spectrum MH+ 538.0.

Provenance & Evidence