4-(Chloromethyl)-1,3-thiazole hydrochloride → HCID 69062105, compound

Participants

Reaction Steps

The procedure described in Example 65 (preparation of starting materials) was repeated using 4-{[5-(2-aminoethoxy)quinazolin-4-yl]amino}-2-chlorophenol and 4-(chloromethyl)-1,3-thiazole hydrochloride to give 5-(2-aminoethoxy)-N-[3-chloro-4-(1,3-thiazol-4-ylmethoxy)phenyl]quinazolin-4-amine in 91% yield; NMR spectrum (DMSO-d6 400 MHz) 3.02-3.19 (bs, 2H), 4.22-4.36 (m, 2H), 5.33 (s, 2H), 7.14 (d, 1H), 7.27-7.40 (m, 2H), 7.67-7.86 (m, 3H), 8.23 (s, 1H), 8.52 (s, 1H), 9.15 (s, 1H) (3 exchangeables); Mass spectrum MH+ 427.9.

Provenance & Evidence