2-Amino-2-methyl-1-propanol → 4-{[5-(2-Amino-2-methylpropoxy)quinazolin-4-yl]amino}-2-methylphenol

Participants

Reaction Steps

The procedure described in Example 3 (preparation of starting materials) was repeated using 2-amino-2-methylpropan-1-ol and 4-[(5-fluoroquinazolin-4-yl)amino]-2-methylphenol (obtained as described in Example 3, preparation of starting materials) to give 4-{[5-(2-amino-2-methylpropoxy)quinazolin-4-yl]amino}-2-methylphenol as a white solid in 78% yield; NMR spectrum (DMSO-d6) 1.34 (s, 6H), 4.23 (s, 2H), 6.97 (d, 1H), 7.18 (d, 1H), 7.35 (d, 1H), 7.52 (dd, 1H), 7.73 (t, 1H), 7.96 (d, 1H), 8.46 (s, 1H), 10.50 (s, 1H); Mass spectrum MH+ 360.

Provenance & Evidence