2-(Chloromethyl)-1,3-thiazole → HCID 57974331, compound

Participants

Reaction Steps

The procedure described in Example 3 was repeated using 2-(chloromethyl)-1,3-thiazole and N-[(2R)-2-({4-[(4-hydroxy-3-methylphenyl)amino]quinazolin-5-yl}oxy)propyl]acetamide (obtained as described in Example 86, preparation of starting materials) to give the title compound as a light brown solid in 25% yield; NMR spectrum (DMSO-d6) 1.41 (d, 3H), 1.77 (s, 3H), 2.25 (s, 3H), 3.42 (dt, 1H), 3.60 (dt, 1H), 4.88 (m, 1H), 5.45 (s, 2H), 7.11 (d, 1H), 7.22 (d, 1H), 7.31 (d, 1H), 7.56 (d, 1H), 7.63 (dd, 1H), 7.68 (t, 1H), 7.76 (d, 1H), 7.83 (d, 1H), 8.23 (t, 1H), 8.43 (s, 1H), 9.97 (s, 1H); Mass spectrum MH+ 464.

Provenance & Evidence