4-(Chloromethyl)-1,3-thiazole → HCID 57974357, compound

Participants

Reaction Steps

The procedure described in Example 3 was repeated using 4-(chloromethyl)-1,3-thiazole and 2-hydroxy-N-[(1R)-2-({4-[(4-hydroxy-3-methylphenyl)amino]quinazolin-5-yl}oxy)-1-methylethyl]-N-methylacetamide (obtained as described in Example 96, preparation of starting materials) to give the title compound as a foam in 29% yield; NMR spectrum (DMSO-d6 373K) 1.26 (d, 3H), 2.24 (s, 3H), 2.83 (s, 3H), 3.97 (s, 2H), 4.35 (m, 1H), 4.46 (t, 1H), 4.95 (m, 1H), 5.24 (s, 2H), 7.08 (d, 1H), 7.18 (d, 2H), 7.35 (d, 1H), 7.42 (s, 1H), 7.46 (d, 1H), 7.70 (m, 1H), 8.41 (s, 1H), 9.07 (s, 1H), 9.50 (s, 1H); Mass spectrum MH+ 494.

Provenance & Evidence