1-Hydroxy-1-cyclopropanecarboxylic acid → N-{(2R)-2-[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]propyl}-1-hydroxy-N-methylcyclopropanecarboxamide

HRID 1864323Notes

Reaction equation

HRID 1864323 reaction equation
[OH:1][C:2]1([C:5]([OH:7])=O)[CH2:4][CH2:3]1.[Cl:8][C:9]1[CH:10]=[C:11]([NH:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][C:32]=3[O:34][C@H:35]([CH3:39])[CH2:36][NH:37][CH3:38])[N:27]=[CH:26][N:25]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>>[Cl:8][C:9]1[CH:10]=[C:11]([NH:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][C:32]=3[O:34][C@H:35]([CH3:39])[CH2:36][N:37]([CH3:38])[C:5]([C:2]3([OH:1])[CH2:4][CH2:3]3)=[O:7])[N:27]=[CH:26][N:25]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1

Participants

3

Reactant 2

HCID 27331601-Hydroxy-1-cyclopropanecarboxylic acidHCID 69055531N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[(1R)-1-methyl-2-(methylamino)ethoxy]quinazolin-4-amine

Product 1

HCID 57974307N-{(2R)-2-[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]propyl}-1-hydroxy-N-methylcyclopropanecarboxamideYield 19%

Procedure

The procedure described in Example 1 was repeated using hydroxy-1-cyclopropane carboxylic acid and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[(1R)-1-methyl-2-(methylamino)ethoxy]quinazolin-4-amine (obtained as described in Example 2.3, preparation of starting materials) to give the title compound as a foam in 19% yield; NMR spectrum (DMSO-d6) 0.70 (s, 4H), 1.40 (d, 3H), 3.23 (s, 3H), 3.36 (m, 1H), 4.19 (m, 1H), 5.15 (m, 1H), 5.29 (s, 2H), 6.20 (s, 1H), 7.24 (m, 2H), 7.35 (m, 2H), 7.58 (m, 2H), 7.71 (t, 1H), 7.87 (dt, 1H), 8.09 (d, 1H), 8.44 (s, 1H), 8.58 (d, 1H), 9.86 (s, 1H); Mass spectrum MH+ 534.

Sources & evidence

ORD record
ord-514e6f1dfaa44683b7258c26a4bcffd1
Source dataset
uspto-grants-2009_12
Patent number
US07625908B2

Reaction notes

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