2-Hydroxy-gamma-butyrolactone, (2S)- → (2S)-2,4-Dihydroxy-N-((2R)-2-{[4-({3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}amino)quinazolin-5-yl]oxy}propyl)butanamide

Participants

Reaction Steps

The procedure described in Example 63 was repeated using 5-[(1R)-2-amino-1-methylethoxy]-N-{3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}quinazolin-4-amine and (S)-α-hydroxybutyrolactone to give the title compound in 53% yield as a solid; NMR Spectrum: (CDCl3) 1.55 (d, 3H), 1.79 (m, 1H), 2.05 (m, 1H), 2.26 (s, 3H), 2.49 (s, 3H), 3.90-3.65 (m, 4H), 4.21 (dd, 1H), 4.94 (m, 1H), 6.96 (m, 2H), 7.11 (d, 1H), 7.23 (dd, 1H), 7.39 (d, 1H), 7.43 (m, 1H), 7.60-7.52 (m, 2H), 7.69 (s, 1H), 8.00 (s, 1H), 8.55 (s, 1H); Mass spectrum: MH+ 518.

Provenance & Evidence