1-(2,5-Xylyl)piperazine → HCID 67141139, compound

Participants

Reaction Conditions

Reaction Steps

(RS)-2-benzenesulfonylamino-3-hydroxy-propionic acid (1.204 g) was dissolved in tetrahydrofuran (15 ml) and cooled to 0° C. 1-(2,5-Dimethylphenyl)-piperazine (1.12 g), (benzotriazol-1-yloxy)-tris-(dimethylamino)-phosphonium-hexafluorophosphate (BOP reagent, 3.26 g) and N-ethyl-diisopropylamine (1.90 g) were added. The mixture was stirred at room temperature for 18 h. Ethyl acetate and a 10% KHSO4 solution were added. The organic phase was washed with water, dried, filtered and evaporated. The product was purified by chromatography (SiO2, cyclohexane/ethyl acetate 1:1=>ethyl acetate) to give (RS)—N-{2-[4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-1-hydroxymethyl-2-oxo-ethyl}-benzenesulfonamide (1.45 g) as a colorless foam. MS: 418.3 ([M+H]+)

Provenance & Evidence