N-(2-Cyanophenyl)piperazine → HCID 25028145, compound

HRID 1864381Notes

Reaction equation

HRID 1864381 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH:5]([C:13](O)=[O:14])[CH2:4][N:3]1[S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([F:28])([F:27])[F:26])(=[O:18])=[O:17].[C:29]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)#[N:30]>>[O:1]=[C:2]1[N:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:5]([C:13]([N:40]2[CH2:39][CH2:38][N:37]([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=3[C:29]#[N:30])[CH2:42][CH2:41]2)=[O:14])[CH2:4][N:3]1[S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([F:27])([F:28])[F:26])(=[O:17])=[O:18]

Participants

3

Reactant 2

HCID 2735875N-(2-Cyanophenyl)piperazineHCID 67141210(RS)-2-oxo-3-phenyl-1-(2-trifluoromethyl-benzenesulfonyl)-imidazolidine-4-carboxylic acid

Product 1

HCID 25028145HCID 25028145, compound

Procedure

In analogy to example 1, (RS)-2-oxo-3-phenyl-1-(2-trifluoromethyl-benzenesulfonyl)-imidazolidine-4-carboxylic acid (example 11, step 4) was coupled with 1-(2-cyanophenyl)-piperazine to give the title compound as a colorless solid. MS: 583.5 ([M+H]+)

Sources & evidence

ORD record
ord-38ed407ee49641849c2ac8dc4ef4bf96
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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