1-(2,5-Xylyl)piperazine → HCID 67141839, compound

HRID 1864394Notes

Reaction equation

HRID 1864394 reaction equation
[C:1]1([S:7]([NH:10][C@H:11]([CH2:15][OH:16])[C:12]([OH:14])=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:19]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[CH3:17][C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:19]=1[N:25]1[CH2:26][CH2:27][N:28]([C:12](=[O:14])[C@H:11]([NH:10][S:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)(=[O:8])=[O:9])[CH2:15][OH:16])[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 705421-(2,5-Xylyl)piperazineHCID 10752872HCID 10752872, compound

Product 1

HCID 67141839HCID 67141839, compound

Procedure

In analogy to example 2, (R)-2-benzenesulfonylamino-3-hydroxy-propionic acid was coupled with 1-(2,5-dimethylphenyl)-piperazine to give N-{(R)-2-[4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-1-hydroxymethyl-2-oxo-ethyl}-benzenesulfonamide.

Sources & evidence

ORD record
ord-506498e094654631866e714c7ae70f52
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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