1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine → HCID 25029292, compound

HRID 1864414Notes

Reaction equation

HRID 1864414 reaction equation
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15](O)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:25][C:26]1[C:27]([N:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)=[N:28][CH:29]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:31]=1>>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([N:39]3[CH2:40][CH2:41][N:36]([C:27]4[C:26]([Cl:25])=[CH:31][C:30]([C:32]([F:35])([F:34])[F:33])=[CH:29][N:28]=4)[CH2:37][CH2:38]3)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 6676191-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazineHCID 67141201(RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid

Product 1

HCID 25029292HCID 25029292, compound

Procedure

In analogy to example 1, (RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid (example 39, step 4) was coupled with 1-[3-chloro-5-(trifluoromethyl)pyrid-2-yl]piperazine to give the title compound as an off-white solid. MS: 600.3 ([M+H]+)

Sources & evidence

ORD record
ord-ce70c49aefff4873bce2274735631846
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

Loading…