2-(Piperazin-1-yl)pyridine-3-carbonitrile → HCID 25029293, compound

HRID 1864415Notes

Reaction equation

HRID 1864415 reaction equation
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([OH:17])=O)[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:25]1[NH:30][CH2:29][CH2:28][N:27]([C:31]2[N:36]=[CH:35][CH:34]=[CH:33][C:32]=2[C:37]#[N:38])[CH2:26]1>>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([N:30]3[CH2:29][CH2:28][N:27]([C:31]4[N:36]=[CH:35][CH:34]=[CH:33][C:32]=4[C:37]#[N:38])[CH2:26][CH2:25]3)=[O:17])[N:12]([CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[C:11]2=[O:24])(=[O:8])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 27372032-(Piperazin-1-yl)pyridine-3-carbonitrileHCID 67141201(RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid

Product 1

HCID 25029293HCID 25029293, compound

Procedure

In analogy to example 1, (RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid (example 39, step 4) was coupled with 1-(2-(3-cyanopyridyl))piperazine to give the title compound as a colorless solid. MS: 523.3 ([M+H]+)

Sources & evidence

ORD record
ord-6fb477c92aaf476388bcd3f1ee975de2
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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