HRID1864417

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID667618

1-[5-(Trifluoromethyl)pyridin-2-yl]piperazine

C10H12F3N3

结构：O=C(O)C1CN(S(=O)(=O)c2ccccc2)C(=O)N1C1CCCCC1

HCID67141201

未命名化合物

PRODUCTS

生成物

结构：O=C(C1CN(S(=O)(=O)c2ccccc2)C(=O)N1C1CCCCC1)N1CCN(c2ccc(C(F)(F)F)cn2)CC1

HCID25029295

未命名化合物

PROCEDURE

实验过程

In analogy to example 1, (RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid (example 39, step 4) was coupled with 1-[5-(trifluoromethyl)pyrid-2-yl]piperazine to give the title compound as a colorless solid. MS: 566.2 ([M+H])

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ada4516affbf429a8ea34899ad4d15be
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07625902B2
来源说明: uspto-grants-2009_12

反应 SMILES

[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15](O)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:25][C:26]([F:40])([F:39])[C:27]1[CH:28]=[CH:29][C:30]([N:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[N:31][CH:32]=1>>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([N:36]3[CH2:37][CH2:38][N:33]([C:30]4[CH:29]=[CH:28][C:27]([C:26]([F:40])([F:25])[F:39])=[CH:32][N:31]=4)[CH2:34][CH2:35]3)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1