1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine → (RS)-1-Benzenesulfonyl-3-cyclohexyl-4-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one

HRID 1864417Notes

Reaction equation

HRID 1864417 reaction equation
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15](O)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:25][C:26]([F:40])([F:39])[C:27]1[CH:28]=[CH:29][C:30]([N:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[N:31][CH:32]=1>>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([N:36]3[CH2:37][CH2:38][N:33]([C:30]4[CH:29]=[CH:28][C:27]([C:26]([F:40])([F:25])[F:39])=[CH:32][N:31]=4)[CH2:34][CH2:35]3)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 6676181-(5-Trifluoromethyl-pyridin-2-yl)-piperazineHCID 67141201(RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid

Product 1

HCID 25029295(RS)-1-Benzenesulfonyl-3-cyclohexyl-4-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one

Procedure

In analogy to example 1, (RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid (example 39, step 4) was coupled with 1-[5-(trifluoromethyl)pyrid-2-yl]piperazine to give the title compound as a colorless solid. MS: 566.2 ([M+H])

Sources & evidence

ORD record
ord-ada4516affbf429a8ea34899ad4d15be
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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