6-(Piperazin-1-yl)pyridine-3-carbonitrile → HCID 25029524, compound

HRID 1864418Notes

Reaction equation

HRID 1864418 reaction equation
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15](O)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:25]1([C:31]2[N:36]=[CH:35][C:34]([C:37]#[N:38])=[CH:33][CH:32]=2)[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([N:28]3[CH2:29][CH2:30][N:25]([C:31]4[CH:32]=[CH:33][C:34]([C:37]#[N:38])=[CH:35][N:36]=4)[CH2:26][CH2:27]3)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:8])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 27371846-(Piperazin-1-yl)pyridine-3-carbonitrileHCID 67141201(RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid

Product 1

HCID 25029524HCID 25029524, compound

Procedure

In analogy to example 1, (RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid (example 39, step 4) was coupled with 6-(piperazino)pyridine-3-carbonitrile to give the title compound as a colorless solid. MS: 523.5 ([M+H]+)

Sources & evidence

ORD record
ord-030c1d4c16dc411c82b7d6eb8c8323f4
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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