1-(3,5-Dichloropyridin-2-yl)piperazine → (RS)-1-Benzenesulfonyl-3-cyclohexyl-4-[4-(3,5-dichloro-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one

HRID 1864419Notes

Reaction equation

HRID 1864419 reaction equation
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15](O)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:25][C:26]1[C:27]([N:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[N:28][CH:29]=[C:30]([Cl:32])[CH:31]=1>>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([N:36]3[CH2:37][CH2:38][N:33]([C:27]4[C:26]([Cl:25])=[CH:31][C:30]([Cl:32])=[CH:29][N:28]=4)[CH2:34][CH2:35]3)=[O:16])[N:12]([CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 27714311-(3,5-Dichloropyridin-2-yl)piperazineHCID 67141201(RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid

Product 1

HCID 25029526(RS)-1-Benzenesulfonyl-3-cyclohexyl-4-[4-(3,5-dichloro-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one

Procedure

In analogy to example 1, (RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid (example 39, step 4) was coupled with 1-(3,5-dichloro-2-pyridinyl)piperazine to give the title compound as a colorless solid. MS: 566.3 ([M+H]+)

Sources & evidence

ORD record
ord-885eafb1338c44a48612194e99848dc1
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

Loading…