HCID 21610469, compound → HCID 25029527, compound

HRID 1864420Notes

Reaction equation

HRID 1864420 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH:5]([C:13](O)=[O:14])[CH2:4][N:3]1[S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([F:28])([F:27])[F:26])(=[O:18])=[O:17].FC([CH:33]1[CH2:38][NH:37][CH2:36][CH2:35][N:34]1[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][N:40]=1)(F)F>>[C:7]1([N:6]2[CH:5]([C:13]([N:37]3[CH2:38][CH2:33][N:34]([C:39]4[C:44]([C:25]([F:28])([F:27])[F:26])=[CH:43][CH:42]=[CH:41][N:40]=4)[CH2:35][CH2:36]3)=[O:14])[CH2:4][N:3]([S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]([F:27])([F:26])[F:28])(=[O:18])=[O:17])[C:2]2=[O:1])[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 21610469HCID 21610469, compoundHCID 67141210(RS)-2-oxo-3-phenyl-1-(2-trifluoromethyl-benzenesulfonyl)-imidazolidine-4-carboxylic acid

Product 1

HCID 25029527HCID 25029527, compound

Procedure

In analogy to example 1, (RS)-2-oxo-3-phenyl-1-(2-trifluoromethyl-benzenesulfonyl)-imidazolidine-4-carboxylic acid (example 11) was coupled with 1-[3-(trifluoromethyl(pyrid-2-yl]piperazine to give the title compound as an off-white solid. MS: 627.8 ([M+H]+)

Sources & evidence

ORD record
ord-b56bd5a92a194553a38a99ad25f51d0a
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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