HRID1864425

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID667619

1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine

C10H11ClF3N3

结构：O=C(O)C1CN(S(=O)(=O)c2ccccc2C(F)(F)F)C(=O)N1c1ccccc1

HCID67141210

未命名化合物

PRODUCTS

生成物

结构：O=C(C1CN(S(=O)(=O)c2ccccc2C(F)(F)F)C(=O)N1c1ccccc1)N1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1

HCID25029766

未命名化合物

PROCEDURE

实验过程

In analogy to example 1, (RS)-2-oxo-3-phenyl-1-(2-trifluoromethyl-benzenesulfonyl)-imidazolidine-4-carboxylic acid (example 11) was coupled with 1-[3-chloro-5-(trifluoromethyl)pyrid-2-yl]piperazine to give the title compound as a colorless solid. MS: 663.5 ([M+H])

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fd8c0b10145b42fcb37be7f4d7e2b676
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07625902B2
来源说明: uspto-grants-2009_12

反应 SMILES

[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH:5]([C:13](O)=[O:14])[CH2:4][N:3]1[S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([F:28])([F:27])[F:26])(=[O:18])=[O:17].[Cl:29][C:30]1[C:31]([N:40]2[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]2)=[N:32][CH:33]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:35]=1>>[Cl:29][C:30]1[C:31]([N:40]2[CH2:45][CH2:44][N:43]([C:13]([CH:5]3[CH2:4][N:3]([S:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[C:25]([F:28])([F:26])[F:27])(=[O:18])=[O:17])[C:2](=[O:1])[N:6]3[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[O:14])[CH2:42][CH2:41]2)=[N:32][CH:33]=[C:34]([C:36]([F:37])([F:38])[F:39])[CH:35]=1