1-(4-Methylpyridin-2-yl)piperazine → (RS)-1-Benzenesulfonyl-3-cyclohexyl-4-[4-(4-methyl-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one

HRID 1864428Notes

Reaction equation

HRID 1864428 reaction equation
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15](O)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:25][C:26]1[CH:31]=[CH:30][N:29]=[C:28]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:27]=1>>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([N:35]3[CH2:36][CH2:37][N:32]([C:28]4[CH:27]=[C:26]([CH3:25])[CH:31]=[CH:30][N:29]=4)[CH2:33][CH2:34]3)=[O:16])[N:12]([CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 27600581-(4-Methylpyridin-2-yl)piperazineHCID 67141201(RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid

Product 1

HCID 25029768(RS)-1-Benzenesulfonyl-3-cyclohexyl-4-[4-(4-methyl-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one

Procedure

In analogy to example 1, (RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid (example 39, step 4) was coupled with 1-(4-methyl-pyridin-2-yl)piperazine to give the title compound as a colorless solid. MS: 512.3 ([M+H]+)

Sources & evidence

ORD record
ord-83a6a385a09f4cb2b1096bd42469e080
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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