HCID 22560452, compound → HCID 25030005, compound

HRID 1864429Notes

Reaction equation

HRID 1864429 reaction equation
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15](O)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:25][C:26]1[CH:33]=[CH:32][C:29]([C:30]#[N:31])=[C:28]([N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[N:27]=1>>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([N:37]3[CH2:38][CH2:39][N:34]([C:28]4[N:27]=[C:26]([CH3:25])[CH:33]=[CH:32][C:29]=4[C:30]#[N:31])[CH2:35][CH2:36]3)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:8])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 22560452HCID 22560452, compoundHCID 67141201(RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid

Product 1

HCID 25030005HCID 25030005, compound

Procedure

In analogy to example 1, (RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid (example 39, step 4) was coupled with 6-methyl-2-piperazin-1-yl-nicotinonitrile (CAS 622405-21-4) to give the title compound as an off-white solid. MS: 537.0 ([M+H]+)

Sources & evidence

ORD record
ord-9e6e091e114c4c1d97a0deb873266dca
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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