3-(1-Piperazinyl)-1,2-benzisothiazole monohydrochloride → (RS)-1-Benzenesulfonyl-4-(4-benzo[d]isothiazol-3-yl-piperazine-1-carbonyl)-3-(2-chloro-phenyl)-imidazolidin-2-one

HRID 1864445Notes

Reaction equation

HRID 1864445 reaction equation
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15](O)=[O:16])[N:12]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:11]2=[O:25])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[N:27]1([C:33]2[C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=3[S:35][N:34]=2)[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([N:30]3[CH2:31][CH2:32][N:27]([C:33]4[C:37]5[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=5[S:35][N:34]=4)[CH2:28][CH2:29]3)=[O:16])[N:12]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:11]2=[O:25])(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 115217113-(1-Piperazinyl)-1,2-benzisothiazole monohydrochlorideHCID 67140727HCID 67140727, compound

Product 1

HCID 25030478(RS)-1-Benzenesulfonyl-4-(4-benzo[d]isothiazol-3-yl-piperazine-1-carbonyl)-3-(2-chloro-phenyl)-imidazolidin-2-one

Procedure

In analogy to example 1, (RS)-1-benzenesulfonyl-3-(2-chloro-phenyl)-2-oxo-imidazolidine-4-carboxylic acid (example 49, step 2) was coupled with 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride to give the title compound as a colorless solid. MS: 581.6 ([M+H]+)

Sources & evidence

ORD record
ord-8e569155ec9b4c17bdcbfbe15ace2e80
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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