1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine → HCID 67141116, compound

HRID 1864453Notes

Reaction equation

HRID 1864453 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C@@H:12]([CH2:16][OH:17])[C:13]([OH:15])=O)(=[O:10])=[O:9].[F:18][C:19]([F:33])([F:32])[C:20]1[C:21]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[N:22][CH:23]=[CH:24][CH:25]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C@@H:12]([CH2:16][OH:17])[C:13](=[O:15])[N:29]1[CH2:30][CH2:31][N:26]([C:21]2[C:20]([C:19]([F:33])([F:18])[F:32])=[CH:25][CH:24]=[CH:23][N:22]=2)[CH2:27][CH2:28]1)(=[O:9])=[O:10]

Participants

3

Reactant 2

HCID 27777861-[3-(Trifluoromethyl)pyridin-2-yl]piperazineHCID 28831676HCID 28831676, compound

Product 1

HCID 67141116HCID 67141116, compound

Procedure

In analogy to example 2, (S)-2-(2-chloro-benzenesulfonylamino)-3-hydroxy-propionic acid was reacted with 1-[3-(trifluoromethyl)pyrid-2-yl]-piperazine to give 2-chloro-N-{(S)-1-hydroxymethyl-2-oxo-2-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-ethyl}-benzenesulfonamide as a colorless foam. MS: 493.0 ([M+H]+)

Sources & evidence

ORD record
ord-8dea301758d248efb05fef7e0743958c
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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