(RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid → HCID 25027249, compound

HRID 1864455Notes

Reaction equation

HRID 1864455 reaction equation
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([OH:17])=O)[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:25][C@@H:26]1[NH:31][CH2:30][CH2:29][N:28]([C:32]2[C:37]([C:38]([F:41])([F:40])[F:39])=[CH:36][CH:35]=[CH:34][N:33]=2)[CH2:27]1>>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([N:31]3[CH2:30][CH2:29][N:28]([C:32]4[C:37]([C:38]([F:41])([F:39])[F:40])=[CH:36][CH:35]=[CH:34][N:33]=4)[CH2:27][C@@H:26]3[CH3:25])=[O:17])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:8])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 67141201(RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acidHCID 68719907HCID 68719907, compound

Product 1

HCID 25027249HCID 25027249, compound

Procedure

In analogy to example 73, (RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid (example 39, step 4) was converted to the acid chloride and subsequently reacted with (S)-3-methyl-1-(3-trifluoromethyl-pyridin-2-yl)-piperazine to give the title compound as a colorless solid. MS: 580.3 ([M+H]+)

Sources & evidence

ORD record
ord-2c86733abe574e6391b2c754dfff2180
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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