Sodium Iodide → (S)-3-Butyl-1-(2-chloro-benzenesulfonyl)-4-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	Sodium Iodide	HCID 5238	—
Reactant	Butyl isocyanate	HCID 8110	—
Reactant	HCID 178519786	HCID 178519786	—
Product	(S)-3-Butyl-1-(2-chloro-benzenesulfonyl)-4-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one	HCID 25027251	—

Reaction Steps

In analogy to example 2, [(S)-1-(2-chloro-benzenesulfonyl)-aziridin-2-yl]-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-methanone (example 72, step 3) was reacted with sodium iodide and n-butylisocyanate to give the title compound as a colorless foam. MS: 574.2 ([M+H]+)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07625902B2
Source dataset	uspto-grants-2009_12
ORD ID	ord-3c931094def24e4e9bc344140a503e48
Source note	uspto-grants-2009_12