HRID1864461

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3811910

2,5-dimethyl-3-piperazin-1-ylpyrazine

C10H16N4

结构：O=C(O)C1CN(S(=O)(=O)c2ccccc2C(F)(F)F)C(=O)N1c1ccccc1

HCID67141210

未命名化合物

PRODUCTS

生成物

结构：Cc1cnc(C)c(N2CCN(C(=O)C3CN(S(=O)(=O)c4ccccc4C(F)(F)F)C(=O)N3c3ccccc3)CC2)n1

HCID25027494

未命名化合物

PROCEDURE

实验过程

In analogy to example 1, (RS)-2-oxo-3-phenyl-1-(2-trifluoromethyl-benzenesulfonyl)-imidazolidine-4-carboxylic acid (example 11) was coupled with 3′,6′-dimethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl (CAS [59215-42-8]) to give the title compound as a colorless solid. MS: 589.0 ([M+H]+)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-596db5d56ef74d1589784d7e4c33d0f0
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07625902B2
来源说明: uspto-grants-2009_12

反应 SMILES

[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH:5]([C:13]([OH:15])=O)[CH2:4][N:3]1[S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([F:28])([F:27])[F:26])(=[O:18])=[O:17].[CH3:29][C:30]1[C:31]([N:37]2[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)=[N:32][C:33]([CH3:36])=[CH:34][N:35]=1>>[CH3:29][C:30]1[C:31]([N:37]2[CH2:38][CH2:39][N:40]([C:13]([CH:5]3[CH2:4][N:3]([S:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[C:25]([F:26])([F:28])[F:27])(=[O:18])=[O:17])[C:2](=[O:1])[N:6]3[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[O:15])[CH2:41][CH2:42]2)=[N:32][C:33]([CH3:36])=[CH:34][N:35]=1