2,5-Dimethyl-3-piperazin-1-ylpyrazine → HCID 25027497, compound

HRID 1864466Notes

Reaction equation

HRID 1864466 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH:13]([C:14]([OH:16])=O)[CH2:12][N:11]([S:17]([CH:20]([CH3:22])[CH3:21])(=[O:19])=[O:18])[C:10]1=[O:23].[CH3:24][C:25]1[C:26]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[N:27][C:28]([CH3:31])=[CH:29][N:30]=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH:13]([C:14]([N:35]2[CH2:36][CH2:37][N:32]([C:26]3[C:25]([CH3:24])=[N:30][CH:29]=[C:28]([CH3:31])[N:27]=3)[CH2:33][CH2:34]2)=[O:16])[CH2:12][N:11]([S:17]([CH:20]([CH3:22])[CH3:21])(=[O:19])=[O:18])[C:10]1=[O:23]

Participants

3

Reactant 2

HCID 38119102,5-Dimethyl-3-piperazin-1-ylpyrazineHCID 67141181(RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid

Product 1

HCID 25027497HCID 25027497, compound

Procedure

In analogy to example 1, (RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid (example 82, step 3) was coupled with 3′,6′-dimethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl (CAS [59215-42-8]) to give the title compound as a colorless solid. MS: 523.2 ([M+H]+)

Sources & evidence

ORD record
ord-8c4b3676881d40bdad38c51a3d8a78cc
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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