HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Chloropyridin-2-yl)piperazine → (RS)-4-[4-(3-Chloro-pyridin-2-yl)-piperazine-1-carbonyl]-3-(2,4-difluoro-phenyl)-1-(propane-2-sulfonyl)-imidazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Chloropyridin-2-yl)piperazine | HCID 11412944 | — |
| Reactant | (RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid | HCID 67141181 | — |
| Product | (RS)-4-[4-(3-Chloro-pyridin-2-yl)-piperazine-1-carbonyl]-3-(2,4-difluoro-phenyl)-1-(propane-2-sulfonyl)-imidazolidin-2-one | HCID 25027714 | — |
Reaction Steps
In analogy to example 1, (RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid (example 82, step 3) was coupled with 1-(3-chloropyridin-2-yl)piperazine to give the title compound as a colorless solid. MS: 527.8 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07625902B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-9dd946a2fe1541fbbe3a675405cc5c06 |
| Source note | uspto-grants-2009_12 |