2,5-Dimethyl-3-piperazin-1-ylpyrazine → HCID 25027716, compound

HRID 1864471Notes

Reaction equation

HRID 1864471 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:12]([C:13](O)=[O:14])[CH2:11][N:10]([S:16]([CH:19]([CH3:21])[CH3:20])(=[O:18])=[O:17])[C:9]1=[O:22].[CH3:23][C:24]1[C:25]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[N:26][C:27]([CH3:30])=[CH:28][N:29]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:12]([C:13]([N:34]2[CH2:35][CH2:36][N:31]([C:25]3[C:24]([CH3:23])=[N:29][CH:28]=[C:27]([CH3:30])[N:26]=3)[CH2:32][CH2:33]2)=[O:14])[CH2:11][N:10]([S:16]([CH:19]([CH3:21])[CH3:20])(=[O:17])=[O:18])[C:9]1=[O:22]

Participants

3

Reactant 2

HCID 38119102,5-Dimethyl-3-piperazin-1-ylpyrazineHCID 67141525HCID 67141525, compound

Product 1

HCID 25027716HCID 25027716, compound

Procedure

In analogy to example 1, (RS)-3-(2-chloro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid (example 85, step 2) was coupled with 3′,6′-dimethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl to give the title compound as a colorless solid. MS: 521.3 ([M+H]+)

Sources & evidence

ORD record
ord-8f612f3ec62941f8a199d063015aa100
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

Loading…