1-(3-Chloropyridin-2-yl)piperazine → HCID 25027715, compound

HRID 1864472Notes

Reaction equation

HRID 1864472 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:12]([C:13](O)=[O:14])[CH2:11][N:10]([S:16]([CH:19]([CH3:21])[CH3:20])(=[O:18])=[O:17])[C:9]1=[O:22].[Cl:23][C:24]1[C:25]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[N:26][CH:27]=[CH:28][CH:29]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:12]([C:13]([N:33]2[CH2:34][CH2:35][N:30]([C:25]3[C:24]([Cl:23])=[CH:29][CH:28]=[CH:27][N:26]=3)[CH2:31][CH2:32]2)=[O:14])[CH2:11][N:10]([S:16]([CH:19]([CH3:21])[CH3:20])(=[O:17])=[O:18])[C:9]1=[O:22]

Participants

3

Reactant 2

HCID 114129441-(3-Chloropyridin-2-yl)piperazineHCID 67141525HCID 67141525, compound

Product 1

HCID 25027715HCID 25027715, compound

Procedure

In analogy to example 1, (RS)-3-(2-chloro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid (example 85, step 2) was coupled with 1-(3-chloropyridin-2-yl)piperazine to give the title compound as a colorless solid. MS: 526.3 ([M+H]+)

Sources & evidence

ORD record
ord-3b280c40c5b24d84b6903aea90c27fda
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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