3-Fluoro-4-methylaniline → HCID 178426501, compound

Participants

Reaction Conditions

Reaction Steps

Solid aluminum chloride (3.66 g, 27.5 mmol, 1 equiv) was added to a neat mixture of 2-bromobenzonitrile (1-1, 5.0 g, 27.5 mmol, 1.0 equiv) and 3-fluoro-4-methylaniline (3.44 g, 27.5 mmol, 1.00 equiv) at 80° C., and the resulting mixture was heated at 140° C. for 30 min. The reaction mixture was cooled to 23° C., allowed to stand for 14 h, then dissolved in chloroform (35 mL). The solution was washed with aqueous NaHCO3 solution (40 mL) and concentrated to afford 2-bromo-N-(3-fluoro-4-methylphenyl)benzenecarboximidamide (1-2) as a dark oil. LRMS m/z: Calc'd for C14H12BrFN2 (M+H) 308.2, found 308.2.

Provenance & Evidence