(2S,3S)-3-methylpyrrolidine-2-carboxylic Acid → HCID 45115923, compound

HRID 1864501Notes

Reaction equation

HRID 1864501 reaction equation
[CH3:1][C@H:2]1[CH2:6][CH2:5][NH:4][C@@H:3]1[C:7]([OH:9])=[O:8].Cl.O[C@H:12]1CCN[C@@H:13]1C(OCC)=O>>[CH3:1][C@H:2]1[CH2:6][CH2:5][NH:4][C@@H:3]1[C:7]([O:9][CH2:12][CH3:13])=[O:8]

Participants

3

Reactant 2

HCID 2724879(2S,3S)-3-methylpyrrolidine-2-carboxylic AcidHCID 69063309HCID 69063309, compound

Product 1

HCID 45115923HCID 45115923, compound

Procedure

The title compound was prepared from (3S)-3-methyl-L-proline, using the methods used to prepare ethyl(3S)-3-hydroxy-L-prolinate hydrochloride. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.1 (d, J=6.8 Hz, 3H) 1.2 (t, J=6.8 Hz, 3H), 1.6 (m, 1H), 2.1 (m, 1H), 2.3 (m, 1H), 3.2 (m, 2H), 3.8 (m, 1H), 4.2 (m, 2H), 4.7 (m, 1H), 9.0(s, 1H), 10.4 (s, 1H).

Sources & evidence

ORD record
ord-0cb85accc0134d5f8cca674dc7b244b0
Source dataset
uspto-grants-2009_12
Patent number
US07625909B2

Reaction notes

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