Acetyl chloride → HCID 69063309, compound

Participants

Reaction Conditions

Reaction Steps

Acetyl chloride (10.8 mL, 153 mmol) was slowly added to ice cold 100% Ethanol (100 mL). (3S)-3-hydroxy-L-proline (5 g, 38.2 mmol) was added and heated at 100° C. for 16 hours. The ester was concentrated to a solid and used without purification. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.2 (t, J=8.1 Hz, 3H), 1.9 (m, 2H), 3.3 (m, 2H), 4.1 (m, 1H), 4.2 (q, J=7.1 Hz, 2H) 4.4 (m, 1H), 9.0 (s, 1H), 10.4 (s, 1H).

Provenance & Evidence