5-bromo-1-methyl-3-nitro-1H-1,2,4-triazole → Methyl 2(s)-ethoxy-3-[4-(2-methyl-5-nitro-2h[1,2,4]triazol-3-yl)phenyl]propanoate

Participants

Reaction Steps

In a manner similar to that of Example 9(e), starting with 0.9 g (4.35 mmol) of 5-bromo-1-methyl-3-nitro-1H-[1,2,4]triazole and 1.9 g (6.5 mmol) of methyl 2(S)-ethoxy-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]propanoate, 0.9 g (62%) of methyl 2(S)-ethoxy-3-[4-(2-methyl-5-nitro-2H-[1,2,4]triazol-3-yl)phenyl]propanoate is obtained in the form of a white solid with a melting point of 119° C.

Provenance & Evidence