Ethyl(4-piperidin-4-yl-piperazin-1-yl)-acetate → (R)-2-[4-(4-ethoxycarbonylmethyl-piperazin-1-yl)-piperidin-1-yl]-1-(2-methoxy-7-methyl-1H-benzimidazol-5-ylmethyl)-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate

HRID 1864637Notes

Reaction equation

HRID 1864637 reaction equation
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@@H:18]([C:32]([OH:34])=O)[CH2:19][C:20]3[CH:30]=[C:29]([CH3:31])[C:23]4[NH:24][C:25]([O:27][CH3:28])=[N:26][C:22]=4[CH:21]=3)=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:35]=[CH:36][CH:37]=[CH:38][C:4]=2[NH:3]1.[NH:39]1[CH2:44][CH2:43][CH:42]([N:45]2[CH2:50][CH2:49][N:48]([CH2:51][C:52]([O:54][CH2:55][CH3:56])=[O:53])[CH2:47][CH2:46]2)[CH2:41][CH2:40]1>>[O:1]=[C:2]1[N:8]([CH:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][C@H:18]([CH2:19][C:20]3[CH:30]=[C:29]([CH3:31])[C:23]4[NH:24][C:25]([O:27][CH3:28])=[N:26][C:22]=4[CH:21]=3)[C:32]([N:39]3[CH2:44][CH2:43][CH:42]([N:45]4[CH2:50][CH2:49][N:48]([CH2:51][C:52]([O:54][CH2:55][CH3:56])=[O:53])[CH2:47][CH2:46]4)[CH2:41][CH2:40]3)=[O:34])=[O:16])[CH2:13][CH2:14]2)[CH2:7][CH2:6][C:5]2[CH:35]=[CH:36][CH:37]=[CH:38][C:4]=2[NH:3]1

Participants

3

Reactant 2

HCID 57848475Ethyl(4-piperidin-4-yl-piperazin-1-yl)-acetateHCID 178493965HCID 178493965, compound

Product 1

HCID 178472621(R)-2-[4-(4-ethoxycarbonylmethyl-piperazin-1-yl)-piperidin-1-yl]-1-(2-methoxy-7-methyl-1H-benzimidazol-5-ylmethyl)-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate

Procedure

Prepared analogously to Example 7i from 150 mg (0.27 mmol) (R)-1-carboxy-2-(2-methoxy-7-methyl-1H-benzimidazol-5-yl)-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate and 85 mg (0.33 mmol) ethyl (4-piperidin-4-yl-piperazin-1-yl)-acetate.

Sources & evidence

ORD record
ord-5ba6a813b2704af1a2b994a1c6c62cbb
Source dataset
uspto-grants-2009_12
Patent number
US07625886B2

Reaction notes

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