HCID 86616914, compound → HCID 86616913, compound

Participants

Reaction Steps

Method D2 (using hydrogen). N-(4-(2-amino-3-nitropyridin-4-yl-oxy)-2-fluorophenyl)-2,2,2-trifluoroacetamide (540 mg, 1.5 mmol) was dissolved in ethanol (15 mL) and AcOEt (5 mL). Palladium 10% on activated carbon (150 mg) was added and the reaction mixture was stirred for 2 hours under hydrogen atmosphere. The catalyst was filtered off and the filtrate evaporated to afford the title compound (490 mg, 100%). 1H-NMR (δ, ppm, DMSO-d6): 4.65 (s, 2H, NH2,Py3), 5.86 (s, 2H, NH2,Py2), 6.23 (d, 1H, HPy,6, J=5.71 Hz), 6.85 (d, 1H, Harom,Ph, J=8.80 Hz), 7.01 (d, 1H, Harom,Ph, J=11.51 Hz), 7.32 (d, 1H, HPy,5, J=5.71 Hz), 7.45 (t, 1H, Harom,Ph, J=8.76 hz), 11.37 (s, 1H, NHCOCF3).

Provenance & Evidence