1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 44185125, compound

Participants

Reaction Steps

Method H2 was used with 7-(4-amino-3-fluorophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one (26 mg, 0.1 mmol) and 1-chloro-4-isocyanato-2-(trifluoromethyl)benzene (23 mg, 0.1 mmol) to afford the title compound (40 mg, 83%). 1H-NMR (δ, ppm, DMSO-d6): 6.45 (d, 1H, HPy,5, J=5.91 Hz), 6.98 (d, 1H, Harom,Ph), 7.23 (d, 1H, Harom,Ph), 7.63 (broad s, 2H, Harom), 7.79 (d, 1H, HPy,6), 8.05 (s, 1H, Harom,Ph), 8.12 (s, 1H, Harom′), 8.69 (s, 1H, NHurea,1), 9.49 (s, 1H, NHurea,3), 11.22 (s, 1H, NHPy3), 11.42 (s, 1H, NHPy2). LC-MS (m/z): 481 (M+H, 100).

Provenance & Evidence