Phenyl isocyanate → HCID 57974509, compound

Participants

Reaction Steps

Method H3 was used with 4-(4-aminophenoxy)-3-nitropyridin-2-amine (50 mg, 0.2 mol) and phenyl isocyanate (22 μL, 0.2 mmol) to afford the title compound (54 mg, 74%). 1H-NMR (δ, ppm, DMSO-d6): 5.96 (d, 1H, HPy,5, J=5.72 Hz), 6.99 (t, 1H, Harom,Ph′,4), 7.13-7.16 (m, 4H, NH2,Py+Harom,Ph,3+5), 7.30 (t, 2H, Harom,Ph′,3+5, J=7.90 Hz), 7.48 (d, 2H, Harom,Ph′,2+6′J=7.69 Hz), 7.55 (d, 2H, Harom,Ph,2+6, J=8.93 Hz), 8.00 (d, 1H, HPy,6, J=5.78 Hz), 8.69 (s, 1H, NHurea,1), 8.81 (s, 1H, NHurea,3); LC-MS (m/z): 366 (M+H, 100).

Provenance & Evidence