1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 44185964, compound

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Reaction Steps

Method H3 was used with 4-(4-amino-3-chlorophenoxy)-3-nitropyridin-2-amine and 4-chloro-3-trifluoromethyl-phenyl isocyanate to afford the title compound (530 mg, 74%). 1H-NMR (δ, ppm, DMSO-d6): 6.05 (d, 1H, HPy,5, J=5.7 Hz), 7.19 (m, 3H, Harom), 7.43 (d, 1H, HPh,11or12, J=2.7 Hz), 7.61 (s, 2H, NH2,Py), 8.01 (d, 1H, HPy,6, J=5.7 Hz), 8.09 (s, 1H, Harom), 8.17 (d, 1H, Harom, J=9.1 Hz), 8.49 (s, 1H, NHurea1), 9.85 (s, 1H, NHurea3). LC-MS (m/z): 502 (M+H, 100).

Provenance & Evidence