1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 44186093, compound

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Reaction Steps

Method H3 was used with 4-(4-amino-3-methylphenoxy)-3-nitropyridin-2-amine and 4-chloro-3-trifluoromethyl-phenyl isocyanate to afford the title compound (582 mg, 78%. 1H-NMR (δ, ppm, DMSO-d6): 2.25 (s, 3H, CH3), 5.95 (d, 1H, HPy,5, J=5.7 Hz), 6.96 (m, 2H, Harom), 7.02 (m, 1H, Harom), 7.12 (s, 2H, NH2,Py), 7.48-7.68 (m, 2H, Harom), 7.73 (d, 1H, Harom), 7.95 (d, 1H, HPy,6, J=5.7 Hz), 8.13 (m, 1H, Harom), 8.65 (s, 1H, NHurea1), 9.99 (s, 1H, NHurea3). LC-MS (m/z): 482 (M+H, 100).

Provenance & Evidence