1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 44186091, compound

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Reaction Steps

Method H3 was used with 4-(4-amino-3-(trifluoromethyl)phenoxy)-3-nitropyridin-2-amine and 4-chloro-3-trifluoromethyl-phenyl isocyanate to afford the title compound (416 mg, 99%). 1H-NMR (δ, ppm, DMSO-d6): 6.06 (d, 1H, HPy,5, J=5.7 Hz), 7.26 (m, 2H, Harom), 7.54 (m, 2H, Harom), 7.64 (s, 2H, NH2,Py), 7.96 (m, 1H, Harom), 8.05 (d, 1H, HPy,6, J=5.7 Hz), 8.11 (m, 1H, Harom), 8.28 (s, 1H, NHurea1), 9.76 (s, 1H, NHurea3). LC-MS (m/z): 536 (M+H, 100).

Provenance & Evidence