1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 44185962, compound

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Reaction Steps

Method H3 was used with 4-(4-amino-2,3-dimethylphenoxy)-3-nitropyridin-2-amine and 4-chloro-3-trifluoromethyl-phenyl isocyanate to afford the title compound (625 mg, 86%) as a yellow powder. 1H-NMR (δ, ppm, DMSO-d6): 2.07 (s, 3H, CH3), 2.19 (s, 3H, CH3), 5.77 (d, 1H, HPy,5, J=5.7 Hz), 6.98 (d, 1H, Harom, J=8.7 Hz), 7.14 (s, 2H, NH2,Py), 7.57 (d, 1H, Harom, J=8.7 Hz), 7.62 (m, 1H, Harom), 7.96 (d, 1H, HPy,6, J=5.7 Hz), 8.12 (m, 1H, Harom), 8.21 (s, 1H, NHurea1), 9.38 (s, 1H, NHurea3). LC-MS (m/z): 496 (M+H, 100).

Provenance & Evidence